Scientific Studies Which Support Isotonix OPC-3®:

:Scientific Studies Which Support Isotonix OPC-3®

• Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
• Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994
• Cesarone, M., et al. Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavanoid Formula OPC-3. Journal Angiology 59: 408-414, 2008.
• Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.
• Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NYAcademy of Sciences 928: 141-156, 2001.
• Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
• Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
• Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
• Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
• Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
• Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
• Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
• Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
• Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
• Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
• Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
• Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
• Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
• Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
• Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
• Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
• Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
• Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
• Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
• Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
• Rohdewald, P. Pycnogenol®. In "Flavonoids in Health and Disease". Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
• Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
• Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
• Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
• Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
• Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
• Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
• Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
• Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
• Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
• Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
• Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
• Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
• Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
• Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
• Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
• Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.
• Ames, BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993.
• Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
• Bagchi, D, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-97, 2000.
• Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002.
• Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993.
• Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002.
• Gibson, L, et al. Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients. J Naturopathic Med 2:45-47, 1991.
• Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990.
• Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983.
• Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26:171-80, 1998.
• Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neuroscience 19: 8114-21, 1999.
• Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects. Br J Nutr 88: 389-98, 2002.
• Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48, 1993.
• Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002.
• Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990.
• Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-37, 2002.
• Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30:1139-43, 1995.
• Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N. Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.
• Qureshi, A, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30:1171-77, 1995.
• Rimbach G, Virgili F, Park YC, Packer L. Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4:171-77, 1999.
• Sobota AE. Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions. J Urology 131:1013-1016, 1984.
• Soloway MS, Smith RA. J Am Med Assoc 260:1465, 1988.
• Tomco, A, et al. Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis. Lipids 30: 1179-83, 1995.
• Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.
• Wilson D et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 24(8):1115-9, 2010.
• Lau B et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004.
• Choi YH, Yan GH. Pycnogenol® inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res 23: 1691-1695, 2009.
• Sharma SC, Sharma S, Gulati OP. Pycnogenol® inhibits the release of histamine from mast cells. Phytother Res, 17: 66-69, 2003.
• Hosseini S, Pishnamazi S, Sadrzadeh MH, Farid F, Farid R, Watson RR. Pycnogenol® in the management of asthma. J Med Food 4: 201-209, 2001.
• Cheshier, J.E et al. Immunomodulation by Pycnogenol® in retro-virus infected or ethanol-fed mice. Life Sci., 58(5): 87-96, 1996.
• Park, Y.C., Rimbach, G., Saliou, C., Valacchi, G. and Packer, L. Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-alpha secretion, and NF-kappaB-dependent gene expression in RAW 264.7 macrophages. FEBS Letters, 465: 93-97, 2000.
• Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
• Liu, F.J., Zhang, Y.X. and Lau B.H.S. Pycnogenol® enhances immune and haemopoietic functions in senescence-accelerated mice.CMLS, Cell. Mol. Life. Sci., 54: 1168-1172, 1998.

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We are different:  - Result

ISOTONIX

Pycnogenol

 

 

 

the Core of Wright loss - as part of the Proven TLS system

TLS® CORE Fat & Carb Inhibitor

 

Read more:  http://ma.imirus.com/Mpowered/book/vpl13/i2/p20/oJOHNINGRID

 

Lepticore - Not just a Weight Loss Ingredient

In this study participants achieved these great results without modifying their food choices.

Read full story: http://ma.imirus.com/Mpowered/book/vpl13/i2/p6/oJOHNINGRID

Inside Isotonix Multivitamin

Inside Isotonix Multivitamin

                                    Daily Value           Isotonix
Vitamin C                         60mg                  150mg
Vitamin B1                       1.5mg                 2.6mg
Vitamin B12                     6mcg                   75 mcg

Vitamin D3                      400 IU                1000IU
Vitamin B2                        1.7mg                 3mg
Vitamin B6                         2mg                   4mg


With100 Percent or more daily value of 15 vitamincs and minerals and other key nutritients to help supplement any dietary needs, Isotonix Multivitamin gets your body what it needs with help from the superior delivery of Isotonix

Read the Topic ： http://ma.imirus.com/Mpowered/book/vpl13/i2/p4/oJOHNINGRID

Rapid Absorption - No Binders or Fillers - Just Results

How does our water filter work?.

Remove pollutants, maintain healthy minerals
Our unique twin cartridge, three-stage filtration system uses a combination of carbon filtration, ion exchange, and sub-micron filtration. Your tap water is forced under pressure over filtration material covering more than two million square feet of surface area. So it reduces over three times more contaminants than leading pitcher filter brands.

Cartridge A

Filters sediment and turbidity
• Reduces microscopic particles
• Improves taste
• Greatly reduces odor

Filters chlorine
• Chlorine is the most concentrated and competitive chemical in tap water

 

Cartridge B

Filters lead and mercury
• Ion exchange reduces heavy metals
• Maintains pH levels
• Improves taste

Filters synthetic chemicals
• Herbicides
• Pesticides
• Industrial solvents

.5-micron absolute filtration
• Removes cysts

Your water becomes contaminated from a variety of sources throughout the process of collection, treatment and delivery. From groundwater contamination at the source to chemical contamination at the treatment facility to rust and lead contamination as the treated water travels through pipes to your home, the water you drink and bathe in can contain dangerous levels of harmful contamination. This continuing level of contamination makes filtering your water a critical component of maintaining your health. With our Countertop water filter filtration technology stands between you and the harmful contamination present in your water supply.

 

 

 

Keep the good ,filter the bad things.

 

Save money, Get Pure water for under $0.03/L.

 

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Why do we need take supplements?

The Need for Nutritional Supplementation

Nutrition 101

 Macronutrients

• · Carbohydrates: starch, sugar
• · Proteins: amino acid
• · Fats: saturated, unsaturated
•  

Micronutrient

• Vitamins
• Fat soluble: A, D, E, K
• Water soluble: B1, B2, B3, B5, B6, B12, C, Folate
•  
• Minerals Mg, Zn, Fe, Cu, I, Ca, Potassium, etc.
• Phytochemicals beta-carotene, salicin

NHANES Data: Summary of Inadequate Intake from Foods
—% of Americans who didn’t meet EAR
—93% Vitamin E - 56% Magnesium,
—44% Vitamin A - 31% Vitamin C
—14% Vitamin B6 - 12% Zinc
— 8% Folic Acid

—% of Americans who didn’t meet AI
—97+% Potassium - 96% Dietary Fiber
—73% Vitamin K - 70% Calcium

 
 

Soil depletion

—"A declining soil fertility, due to a lack of organic material, major elements, and trace minerals, is responsible for poor crops and in turn for pathological conditions in animals fed deficient foods from such soils, and that mankind is no exception."

 

Dr. William A. Albrecht

Chairman of the Department of Soils at the University of Missouri

 

True

 

Animals require at least: 45 minerals, 12 essential amino acids, 16 vitamins, and 3 essential fatty acids (The National Science Foundation )

 

—The human body requires at least 60 minerals for optimal health and basically the same other essentials as animals. (Gary Price Todd, MD)

 

—But, only 8 minerals are available in any kind of quantity in most of the food we eat today.

 

 

Why Nutrition is very important to us?

 





”You can trace every sickness, every disease, and every ailment to a mineral deficiency.”

Dr. Linus Pauling, the two-time Nobel Prize winner

Our immunity very much parallels the immunity of the land. 

Dr. Jensen's book, Empty Harvest

In the absence of minerals, vitamins have no function. Lacking vitamins, the system can make use of the minerals, but lacking minerals, vitamins are useless.

Dr. Charles Northen, MD

 

 



Why Choose Market America products?

1.Good bioavailability

2.Comprehensive and synergistic formulations

3.Tasty and palatable

4.Scientifically based

5.High standards for quality control (QC).

6.Good label information including warnings and contraindication.

 

 

 

 



You can only buy Isotonix from Market America Distributor or online Check the Isotonix Products :

 

 

 



Wealth Inequality in America Video - What this really means

Wealth Inequality in America Video - What this really means

Many people have seen this video flying around social media titled "Wealth Inequality in America." If you haven't seen the video, you can check it out.

I've read numerous articles and comments about this video and was taken back a bit from what I read. This video seems to have generated anger as well as a sense of unfairness. I read a few comments that even suggested that the government needs to take from the "rich" and spread it evenly throughout the "less fortunate". I was appalled and shocked at the general attitude of people and needed to shed some light on what this video really proves.

I believe the true wake up call that this video shows is that people who have just trusted in average effort, average actions and average thinking are now paralyzed. That may be brutal to hear but I think being blunt is something people need in order to wake up. This video implies to the average, that there's a shortage of what most people can have and that it's only reserved for the top. That's just not true.

Money.

There is no shortage of money. Money is printed to the tune of 85 billion dollars a month, thanks to the federal reserve. The situation would be unfair if there was only "x" amount of money and only a few people had it all and no one else could get more. But the fact is that there is no shortage of money which means that if you want more - there's more to go around. You just need to know how to get more of it.

Effort.

There's also no shortage on effort. As far as I can see, people may not have money to invest for advertising, or capital to create a business but everyone has unlimited effort. You can produce more effort than the top money earners in the country. It's not like only so much effort exists and you're out of luck because someone else is using it all.

Opportunity.

Right now people are reducing and minimizing while others are looking at this recession as an opportunity to advance financially. Are you sitting hoping, wishing, praying, being a victim? Or are you passing by those people because you're looking at this as a huge opportunity to advance.

Action.

Love this word. There is no limit to the amount of action you are able to take. You can sit and take no action like the majority of people (which is why they aren't financially successful) or you can take massive action and smoke the market place and create success.

Here's what it boils down to. This chart shows that people are frozen, paralyzed and are waving the white flag. We have a nation of people who are falling into the victim role rather than taking massive amounts of action. 99% of the country shouldn't wish to be handed more - they should wish to become more. We need to look at this as a wake up call that the safe middle class is no longer a safe place to enjoy a nice average income - it is a mindset that will create financial ruin. There is a new class level that has been created and will become the new average - you can choose to find passion, take massive amounts of action and be willing to put in effort and achieve success OR you can choose to hate the rich, wish they didn't put effort into their lives, pray that someone will take care of you and blame the system for your situation.

This is the Middle Class wake up call. Wake Up! Don't give in, dust yourself off and take responsibility that average is no longer good enough. You need to look for ways to create more - your job or lack of job is not good enough any more. You need to look at this not as a recession but an opportunity to create more. You have to look for a plan of action and take massive action and don't stop till you have reach your financial goals. Once you've reach your goals, you need to set new goals and go after those. This is the new "middle class'. It's a class of achievers, the doers, the motivated and the motivators. This is the new America and you can either participate and create your America Dream, or you can play the average card and watch as more income comes out of your household and goes to those who are taking action. The America Dream is alive - but she's limited herself to those who are taking action, finding solutions and creating more opportunities - not those who are looking for a hand out.

Start researching opportunities. How can you earn more money in addition to what you're making? How can you get more time in your life? Who can you ask to mentor you and help you. If you don't know where to start, check out some free info at  http://www.apluschoice.net